When the naval construction designer Oliver Reed (Kent Smith) meets the Serbian Irena Dubrovna Reed (Simone Simon) in the zoo, he flirts with her and they sooner fall in love and marry each other. However, Irena is afraid of an ancient course of her town that women can not be touched by a man, otherwise she will transform in a panther, and the couple does not consummate their marriage. Irena is sent for treatment with the psychiatrist Dr. Louis Judd (Tom Conway), while Oliver looks for "consolation" with his colleague Alice Moore (Jane Randolph). When Irena sees that she is losing Oliver to Alice, she becomes jealous and hateful, leading to a tragic end.
一群亲密的好朋友决定前往西弗吉尼亚州徒步旅行,却意外遇到在对陌生人不友好的部落,这是一个已经在山里居住了数百年的部落。面对好朋友相继遇难,女主角利用自己的勇敢和智慧保护自己,最终虎口脱险的故事。