1865年夏的京都，德川幕府创建的法度森严的新撰组遴选新队员，下级武士田代彪蔵（浅野忠信）和美少年加纳惣三郎（松田龙平）因剑术出类拔萃被选中。初入队，加纳即出色地完成处决破坏法度的队员的命令。队中有人传言加纳和田代是一对，同时加纳与另一队员汤泽藤次郎也保有暧昧关系，不久，汤泽被杀，几番带加纳去欢场的山崎也遭人偷袭，新撰组正负组长近藤和土方（北野武）根据现场留下的短刀将田代定为凶手，并命加纳前去讨伐田代，然而实际上，一切死亡事件都系加纳精心策划，他的美貌已经使整个新撰组陷入混乱中。

米尔德雷德（弗兰西斯·麦克多蒙德 Frances McDormand 饰）的女儿在外出时惨遭奸杀，米尔德雷德和丈夫查理（约翰·哈克斯 John Hawkes 饰）之间的婚姻因此走到了尽头，如今，她同儿子罗比（卢卡斯·赫奇斯 Lucas Hedges饰）过着相依为命的生活。一晃眼几个月过去了，案件仍然没有告破预兆，而警方似乎早已经将注意力从案子上转移了开来。被绝望和痛苦缠绕的米尔德雷德租下了高速公路边上的三块巨型广告牌，在上面控诉警方办案无能，并将矛头直接对准了警察局局长威洛比（伍迪·哈里森 Woody Harrelson 饰）。实际上，威洛比一直隐瞒着自己身患绝症命不久矣的事实。因为这三块广告牌，米尔德雷德和威洛比的生活发生了翻天覆地的变化。

讲述一个非职业爱好者组成的地方交响乐团追逐梦想的故事

Miyako is a frustrated insurance saleswoman stuck in a major dry spell. She tries every trick in the book, including aggressive flirting, which gets her plenty of gropers but no buyers. One day while venturing down a narrow stairwell, she injures her ankle and happens upon Mitsuru who works for some mysterious foreign company. Decked out in high goth style -- complete with long inky black hair and mascaraed eyes -- Mitsuru cuts quite an odd figure, yet his seductive though menacing ways make him difficult for Miyako to resist. Escorting her to his office to treat her ankle, Miyako notices that his all-female staff seem more glassy-eyed and soul-deadened than the average office workers. In fact, they seem almost like zombies. Later, weird things start happening. Mitsuko finds vomit on her doorstep, she seems to be tailed by a shadowy woman in a red dress, and most strikingly, she finds herself utterly powerless against Mitsuru's advances. Soon she is offered a job at Mitsuru's office among the undead and the damned. Does Miyako's potential new place of employment at least offer stock options in exchange for her soul?